Receptor-Activator of Nuclear KappaB Ligand Expression as a New Therapeutic Target in Primary Bone Tumors

The receptor-activator of nuclear kappaB ligand (RANKL) signaling pathway plays an important role in the regulation of bone growth and mediates the formation and activation of osteoclasts. Osteoclasts are involved in significant bone resorption and destruction. Denosumab is a fully human monoclonal...

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Udgivet i:PLoS One
Main Authors: Yamagishi, Tetsuro, Kawashima, Hiroyuki, Ogose, Akira, Ariizumi, Takashi, Sasaki, Taro, Hatano, Hiroshi, Hotta, Tetsuo, Endo, Naoto
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862691/
https://ncbi.nlm.nih.gov/pubmed/27163152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154680
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