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Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton
Mutations that impair the proliferation of enteric neural crest-derived cells (ENCDC) cause Hirschsprung disease, a potentially lethal birth defect where the enteric nervous system (ENS) is absent from distal bowel. Inosine 5′ monophosphate dehydrogenase (IMPDH) activity is essential for de novo GMP...
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| Опубликовано в: : | Dev Biol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4862663/ https://ncbi.nlm.nih.gov/pubmed/26546974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.11.004 |
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