NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines including IL-1β and IL-18. We show that NLRP3 inflammasome activation is restricted to interphase of the cell cycle by NEK7, a serine/threonine kinase previously implicated in mitosi...

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Pubblicato in:Nat Immunol
Autori principali: Shi, Hexin, Wang, Ying, Li, Xiaohong, Zhan, Xiaoming, Tan, Miao, Fina, Maggy, Su, Lijing, Pratt, David, Bu, Chun Hui, Hildebrand, Sara, Lyon, Stephen, Scott, Lindsay, Quan, Jiexia, Sun, Qihua, Russell, Jamie, Arnett, Stephanie, Jurek, Peter, Chen, Ding, Kravchenko, Vladimir V., Mathison, John C., Moresco, Eva Marie Y., Monson, Nancy L., Ulevitch, Richard J., Beutler, Bruce
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862588/
https://ncbi.nlm.nih.gov/pubmed/26642356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3333
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