NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines including IL-1β and IL-18. We show that NLRP3 inflammasome activation is restricted to interphase of the cell cycle by NEK7, a serine/threonine kinase previously implicated in mitosi...

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Foilsithe in:Nat Immunol
Main Authors: Shi, Hexin, Wang, Ying, Li, Xiaohong, Zhan, Xiaoming, Tan, Miao, Fina, Maggy, Su, Lijing, Pratt, David, Bu, Chun Hui, Hildebrand, Sara, Lyon, Stephen, Scott, Lindsay, Quan, Jiexia, Sun, Qihua, Russell, Jamie, Arnett, Stephanie, Jurek, Peter, Chen, Ding, Kravchenko, Vladimir V., Mathison, John C., Moresco, Eva Marie Y., Monson, Nancy L., Ulevitch, Richard J., Beutler, Bruce
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862588/
https://ncbi.nlm.nih.gov/pubmed/26642356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3333
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