Novobiocin Susceptibility of MukBEF-Deficient Escherichia coli Is Combinatorial with Efflux and Resides in DNA Topoisomerases

Condensins play a key role in the global organization of bacterial chromosomes. In Escherichia coli, the inactivation of its sole condensin MukBEF induces severe growth defects and renders cells hypersusceptible to novobiocin. We report here that this hypersusceptibility can be observed in TolC-defi...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Petrushenko, Zoya M., Zhao, Hang, Zgurskaya, Helen I., Rybenkov, Valentin V.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862531/
https://ncbi.nlm.nih.gov/pubmed/26926630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03102-15
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