Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China

Mycobacterium tuberculosis can acquire resistance to rifampin (RIF) through mutations in the rpoB gene. This is usually accompanied by a fitness cost, which, however, can be mitigated by secondary mutations in the rpoA or rpoC gene. This study aimed to identify rpoA and rpoC mutations in clinical M....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Li, Qin-jing, Jiao, Wei-wei, Yin, Qing-qin, Xu, Fang, Li, Jie-qiong, Sun, Lin, Xiao, Jing, Li, Ying-jia, Mokrousov, Igor, Huang, Hai-rong, Shen, A-dong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2016
Aiheet:
Mechanisms of Resistance
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862491/
https://ncbi.nlm.nih.gov/pubmed/26902762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02358-15
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