Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China

Mycobacterium tuberculosis can acquire resistance to rifampin (RIF) through mutations in the rpoB gene. This is usually accompanied by a fitness cost, which, however, can be mitigated by secondary mutations in the rpoA or rpoC gene. This study aimed to identify rpoA and rpoC mutations in clinical M....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Li, Qin-jing, Jiao, Wei-wei, Yin, Qing-qin, Xu, Fang, Li, Jie-qiong, Sun, Lin, Xiao, Jing, Li, Ying-jia, Mokrousov, Igor, Huang, Hai-rong, Shen, A-dong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862491/
https://ncbi.nlm.nih.gov/pubmed/26902762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02358-15
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