Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease

OBJECTIVE: We aimed to test whether in vivo levels of magnetic resonance spectroscopy (MRS) metabolites myo-inositol (mI), N-acetylaspartate (NAA), and choline are abnormal already during preclinical Alzheimer disease (AD), relating these changes to amyloid or tau pathology, and functional connectiv...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Voevodskaya, Olga, Sundgren, Pia C., Strandberg, Olof, Zetterberg, Henrik, Minthon, Lennart, Blennow, Kaj, Wahlund, Lars-Olof, Westman, Eric, Hansson, Oskar
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862247/
https://ncbi.nlm.nih.gov/pubmed/27164711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000002672
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