Osthole inhibits histamine-dependent itch via modulating TRPV1 activity

Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imagi...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Yang, Niu-Niu, Shi, Hao, Yu, Guang, Wang, Chang-Ming, Zhu, Chan, Yang, Yan, Yuan, Xiao-Lin, Tang, Min, Wang, Zhong-li, Gegen, Tana, He, Qian, Tang, Kehua, Lan, Lei, Wu, Guan-Yi, Tang, Zong-Xiang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861971/
https://ncbi.nlm.nih.gov/pubmed/27160770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25657
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