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Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs

We previously reported that duodenal administration of the natural flavone acacetin can effectively prevent the induction of experimental atrial fibrillation (AF) in canines; however, it may not be used intravenously to terminate AF due to its poor water-solubility. The present study was to design a...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Liu, Hui, Wang, Ya-Jing, Yang, Lei, Zhou, Mei, Jin, Man-Wen, Xiao, Guo-Sheng, Wang, Yan, Sun, Hai-Ying, Li, Gui-Rong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861903/
https://ncbi.nlm.nih.gov/pubmed/27160397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25743
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