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Mesenchymal Stem Cells Attenuate NADPH Oxidase-Dependent High Mobility Group Box 1 Production and Inhibit Abdominal Aortic Aneurysms

OBJECTIVE: Abdominal aortic aneurysm (AAA) formation is characterized by inflammation, smooth muscle activation and matrix degradation. This study tests the hypothesis that macrophage-produced high mobility group box1 (HMGB1) production is dependent on NADPH oxidase (Nox2) which leads to increase in...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Sharma, Ashish K., Salmon, Morgan D., Lu, Guanyi, Su, Gang, Pope, Nicolas H., Smith, Joseph R., Weiss, Mark L., Upchurch, Gilbert R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861899/
https://ncbi.nlm.nih.gov/pubmed/26988591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307373
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