Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

IMPORTANCE: Synaptic loss is an early pathologic substrate of Alzheimer disease (AD). Neurogranin is a postsynaptic neuronal protein that has demonstrated utility as a cerebrospinal fluid (CSF) marker of synaptic loss in AD. OBJECTIVE: To investigate the diagnostic and prognostic utility of CSF neur...

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Pubblicato in:JAMA Neurol
Autori principali: Tarawneh, Rawan, D’Angelo, Gina, Crimmins, Dan, Herries, Elizabeth, Griest, Terry, Fagan, Anne M., Zipfel, Gregory J., Ladenson, Jack H., Morris, John C., Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861689/
https://ncbi.nlm.nih.gov/pubmed/27018940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2016.0086
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