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A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

Cardiac fibroblasts support heart function, and aberrant fibroblast signaling can lead to fibrosis and cardiac dysfunction. Yet how signaling molecules drive myofibroblast differentiation and fibrosis in the complex signaling environment of cardiac injury remains unclear. We developed a large-scale...

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Foilsithe in:J Mol Cell Cardiol
Main Authors: Zeigler, A.C., Richardson, W. J., Holmes, J. W., Saucerman, J. J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861657/
https://ncbi.nlm.nih.gov/pubmed/27017945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.03.008
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