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ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress

ATR (ataxia telangiectasia and Rad-3-related) is a protein kinase that maintains genome stability and halts cell cycle phase transitions in response to DNA lesions that block DNA polymerase movement. These DNA replication-associated features of ATR function have led to the emergence of ATR kinase in...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Kemp, Michael G., Sancar, Aziz
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861496/
https://ncbi.nlm.nih.gov/pubmed/26940878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.719740
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