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The Luminescent Oligothiophene p-FTAA Converts Toxic Aβ(1–42) Species into Nontoxic Amyloid Fibers with Altered Properties
Aggregation of the amyloid-β peptide (Aβ) in the brain leads to the formation of extracellular amyloid plaques, which is one of the pathological hallmarks of Alzheimer disease (AD). It is a general hypothesis that soluble prefibrillar assemblies of the Aβ peptide, rather than mature amyloid fibrils,...
Guardat en:
| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4861488/ https://ncbi.nlm.nih.gov/pubmed/26907684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.696229 |
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