Transcriptional Reprogramming and Resistance to Colonic Mucosal Injury in Poly(ADP-ribose) Polymerase 1 (PARP1)-deficient Mice

Poly(ADP-ribose) polymerases (PARPs) synthesize and bind branched polymers of ADP-ribose to acceptor proteins using NAD as a substrate and participate in the control of gene transcription and DNA repair. PARP1, the most abundant isoform, regulates the expression of proinflammatory mediator cytokines...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Larmonier, Claire B., Shehab, Kareem W., Laubitz, Daniel, Jamwal, Deepa R., Ghishan, Fayez K., Kiela, Pawel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861461/
https://ncbi.nlm.nih.gov/pubmed/26912654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.714386
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