Transcriptional Reprogramming and Resistance to Colonic Mucosal Injury in Poly(ADP-ribose) Polymerase 1 (PARP1)-deficient Mice

Poly(ADP-ribose) polymerases (PARPs) synthesize and bind branched polymers of ADP-ribose to acceptor proteins using NAD as a substrate and participate in the control of gene transcription and DNA repair. PARP1, the most abundant isoform, regulates the expression of proinflammatory mediator cytokines...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Larmonier, Claire B., Shehab, Kareem W., Laubitz, Daniel, Jamwal, Deepa R., Ghishan, Fayez K., Kiela, Pawel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861461/
https://ncbi.nlm.nih.gov/pubmed/26912654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.714386
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