A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma

RASSF1A (Ras association domain containing family 1A), a tumor suppressor gene that is frequently inactivated in human cancers, is phosphorylated by Ataxia Telangiectasia Mutated (ATM) on Ser131 upon DNA damage, leading to activation of a p73-dependent apoptotic response. A single nucleotide polymor...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Yee, Karen S., Grochola, Lukasz, Hamilton, Garth, Grawenda, Anna, Bond, Elisabeth E., Taubert, Helge, Wurl, Peter, Bond, Gareth L., O’Neill, Eric
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861210/
https://ncbi.nlm.nih.gov/pubmed/22389451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2906
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