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A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma
RASSF1A (Ras association domain containing family 1A), a tumor suppressor gene that is frequently inactivated in human cancers, is phosphorylated by Ataxia Telangiectasia Mutated (ATM) on Ser131 upon DNA damage, leading to activation of a p73-dependent apoptotic response. A single nucleotide polymor...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4861210/ https://ncbi.nlm.nih.gov/pubmed/22389451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2906 |
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