Senataxin controls meiotic silencing through ATR activation and chromatin remodeling

Senataxin, defective in ataxia oculomotor apraxia type 2, protects the genome by facilitating the resolution of RNA–DNA hybrids (R-loops) and other aspects of RNA processing. Disruption of this gene in mice causes failure of meiotic recombination and defective meiotic sex chromosome inactivation, le...

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Bibliographic Details
Published in:Cell Discov
Main Authors: Yeo, Abrey J, Becherel, Olivier J, Luff, John E, Graham, Mark E, Richard, Derek, Lavin, Martin F
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860845/
https://ncbi.nlm.nih.gov/pubmed/27462424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.25
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