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Senataxin controls meiotic silencing through ATR activation and chromatin remodeling
Senataxin, defective in ataxia oculomotor apraxia type 2, protects the genome by facilitating the resolution of RNA–DNA hybrids (R-loops) and other aspects of RNA processing. Disruption of this gene in mice causes failure of meiotic recombination and defective meiotic sex chromosome inactivation, le...
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| Pubblicato in: | Cell Discov |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860845/ https://ncbi.nlm.nih.gov/pubmed/27462424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.25 |
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