Metabolic reprogramming and dependencies associated with epithelial cancer stem cells independent of the epithelial-mesenchymal transition program

In solid tumors, cancer stem cells (CSCs) can arise independently of epithelial-mesenchymal transition (EMT). In spite of recent efforts, the metabolic reprogramming associated with CSC phenotypes uncoupled from EMT is poorly understood. Here, by using metabolomic and fluxomic approaches, we identif...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Aguilar, Esther, de Mas, Igor Marin, Zodda, Erika, Marin, Silvia, Morrish, Fionnuala, Selivanov, Vitaly, Meca-Cortés, Óscar, Delowar, Hossain, Pons, Mònica, Izquierdo, Inés, Celià-Terrassa, Toni, de Atauri, Pedro, Centelles, Josep J, Hockenbery, David, Thomson, Timothy M, Cascante, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860823/
https://ncbi.nlm.nih.gov/pubmed/27146024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2286
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