The redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss

p66(shc), a member of the ShcA protein family, is essential for cellular response to oxidative stress, and elicits the formation of mitochondrial Reactive Oxygen Species (ROS), thus promoting vasomotor dysfunction and inflammation. Accordingly, mice lacking the p66 isoform display increased resistan...

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Publicado en:Sci Rep
Autores principales: Fetoni, A. R., Eramo, S. L. M., Paciello, F., Rolesi, R., Samengo, D., Paludetti, G., Troiani, D., Pani, G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860599/
https://ncbi.nlm.nih.gov/pubmed/27157635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25450
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