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RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure
The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860253/ https://ncbi.nlm.nih.gov/pubmed/27153532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.034 |
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