Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II

Activation triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We show that the human CaMKII holoenzyme exists in...

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發表在:eLife
Main Authors: Bhattacharyya, Moitrayee, Stratton, Margaret M, Going, Catherine C, McSpadden, Ethan D, Huang, Yongjian, Susa, Anna C, Elleman, Anna, Cao, Yumeng Melody, Pappireddi, Nishant, Burkhardt, Pawel, Gee, Christine L, Barros, Tiago, Schulman, Howard, Williams, Evan R, Kuriyan, John
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2016
主題:
Biochemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859805/
https://ncbi.nlm.nih.gov/pubmed/26949248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13405
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