Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II

Activation triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We show that the human CaMKII holoenzyme exists in...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Bhattacharyya, Moitrayee, Stratton, Margaret M, Going, Catherine C, McSpadden, Ethan D, Huang, Yongjian, Susa, Anna C, Elleman, Anna, Cao, Yumeng Melody, Pappireddi, Nishant, Burkhardt, Pawel, Gee, Christine L, Barros, Tiago, Schulman, Howard, Williams, Evan R, Kuriyan, John
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Biochemistry
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859805/
https://ncbi.nlm.nih.gov/pubmed/26949248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13405
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