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Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution

Granzyme B is one of the key effector molecules in our defense against viruses and intracellular bacteria. This serine protease together with the pore forming protein perforin, induces caspase or Bid-dependent apoptosis in target cells. Here we present the first characterization of a granzyme B homo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fu, Zhirong, Thorpe, Michael, Akula, Srinivas, Hellman, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859502/
https://ncbi.nlm.nih.gov/pubmed/27152961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154886
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