HECT‐Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin‐Interacting Protein and Ameliorates Reactive Oxygen Species–Induced Cardiotoxicity

BACKGROUND: The homologous to the E6‐AP carboxyl terminus (HECT)–type ubiquitin E3 ligase ITCH is an enzyme that plays a pivotal role in posttranslational modification by ubiquitin proteasomal protein degradation. Thioredoxin‐interacting protein (TXNIP) is a negative regulator of the thioredoxin sys...

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Publicado en:J Am Heart Assoc
Autores principales: Otaki, Yoichiro, Takahashi, Hiroki, Watanabe, Tetsu, Funayama, Akira, Netsu, Shunsuke, Honda, Yuki, Narumi, Taro, Kadowaki, Shinpei, Hasegawa, Hiromasa, Honda, Shintaro, Arimoto, Takanori, Shishido, Tetsuro, Miyamoto, Takuya, Kamata, Hideaki, Nakajima, Osamu, Kubota, Isao
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859366/
https://ncbi.nlm.nih.gov/pubmed/26796253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002485
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