MNase titration reveals differences between nucleosome occupancy and chromatin accessibility

Chromatin accessibility plays a fundamental role in gene regulation. Nucleosome placement, usually measured by quantifying protection of DNA from enzymatic digestion, can regulate accessibility. We introduce a metric that uses micrococcal nuclease (MNase) digestion in a novel manner to measure chrom...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Mieczkowski, Jakub, Cook, April, Bowman, Sarah K., Mueller, Britta, Alver, Burak H., Kundu, Sharmistha, Deaton, Aimee M., Urban, Jennifer A., Larschan, Erica, Park, Peter J., Kingston, Robert E., Tolstorukov, Michael Y.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859066/
https://ncbi.nlm.nih.gov/pubmed/27151365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11485
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