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MNase titration reveals differences between nucleosome occupancy and chromatin accessibility
Chromatin accessibility plays a fundamental role in gene regulation. Nucleosome placement, usually measured by quantifying protection of DNA from enzymatic digestion, can regulate accessibility. We introduce a metric that uses micrococcal nuclease (MNase) digestion in a novel manner to measure chrom...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4859066/ https://ncbi.nlm.nih.gov/pubmed/27151365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11485 |
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