Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming

Chromatin structure determines DNA accessibility. We compare nucleosome occupancy in mouse and human embryonic stem cells (ESCs), induced-pluripotent stem cells (iPSCs) and differentiated cell types using MNase-seq. To address variability inherent in this technique, we developed a bioinformatic appr...

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Autori principali: West, Jason A., Cook, April, Alver, Burak H., Stadtfeld, Matthias, Deaton, Aimee M., Hochedlinger, Konrad, Park, Peter J., Tolstorukov, Michael Y., Kingston, Robert E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217530/
https://ncbi.nlm.nih.gov/pubmed/25158628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5719
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