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Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development

BACKGROUND: Recent advances in sequencing technologies enable the large-scale identification of genes that are affected by various genetic alterations in cancer. However, understanding tumor development requires insights into how these changes cause altered protein function and impaired network regu...

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Detalhes bibliográficos
Publicado no:Biol Direct
Main Authors: Mészáros, Bálint, Zeke, András, Reményi, Attila, Simon, István, Dosztányi, Zsuzsanna
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858844/
https://ncbi.nlm.nih.gov/pubmed/27150584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-016-0125-6
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