Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice

Dopamine β-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells. DBH deficiency prevents NE production and causes sympathetic failure, hypotension and ptosis in humans and mice; DBH knockout (Dbh -/-) mice reveal other NE deficiency phenotypes including e...

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Publicado en:PLoS One
Main Authors: Cubells, Joseph F., Schroeder, Jason P., Barrie, Elizabeth S., Manvich, Daniel F., Sadee, Wolfgang, Berg, Tiina, Mercer, Kristina, Stowe, Taylor A., Liles, L. Cameron, Squires, Katherine E., Mezher, Andrew, Curtin, Patrick, Perdomo, Dannie L., Szot, Patricia, Weinshenker, David
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857931/
https://ncbi.nlm.nih.gov/pubmed/27148966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154864
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