Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice

Dopamine β-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells. DBH deficiency prevents NE production and causes sympathetic failure, hypotension and ptosis in humans and mice; DBH knockout (Dbh -/-) mice reveal other NE deficiency phenotypes including e...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cubells, Joseph F., Schroeder, Jason P., Barrie, Elizabeth S., Manvich, Daniel F., Sadee, Wolfgang, Berg, Tiina, Mercer, Kristina, Stowe, Taylor A., Liles, L. Cameron, Squires, Katherine E., Mezher, Andrew, Curtin, Patrick, Perdomo, Dannie L., Szot, Patricia, Weinshenker, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857931/
https://ncbi.nlm.nih.gov/pubmed/27148966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154864
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