Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice

Dopamine β-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells. DBH deficiency prevents NE production and causes sympathetic failure, hypotension and ptosis in humans and mice; DBH knockout (Dbh -/-) mice reveal other NE deficiency phenotypes including e...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Cubells, Joseph F., Schroeder, Jason P., Barrie, Elizabeth S., Manvich, Daniel F., Sadee, Wolfgang, Berg, Tiina, Mercer, Kristina, Stowe, Taylor A., Liles, L. Cameron, Squires, Katherine E., Mezher, Andrew, Curtin, Patrick, Perdomo, Dannie L., Szot, Patricia, Weinshenker, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857931/
https://ncbi.nlm.nih.gov/pubmed/27148966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154864
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge