N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys

AIM: To investigate the effects of ROS scavenger N-acetylcysteine (NAC) on angiotensin II (Ang II)-mediated renal fibrosis in vivo and in vitro. METHODS: Mice were subjected to unilateral ureteral obstruction (UUO), and then treated with vehicle or NAC (250 mg/kg, ip) for 7 days. Histological change...

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Publicat a:Acta Pharmacol Sin
Autors principals: Shen, Yang, Miao, Nai-jun, Xu, Jin-lan, Gan, Xin-xin, Xu, Dan, Zhou, Li, Xue, Hong, Zhang, Wei, Lu, Li-min
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857549/
https://ncbi.nlm.nih.gov/pubmed/27041464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.12
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