DL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes

AIM: DL0805-2 [N-(1H-indazol-5-yl)-1-(4-methylbenzyl) pyrrolidine-3-carboxamide] is a DL0805 derivative with more potent vasorelaxant activity and lower toxicity. This study was conducted to investigate the vasorelaxant mechanisms of DL0805-2 on angiotensin II (Ang II)-induced contractions of rat th...

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Detaylı Bibliyografya
Yayımlandı:Acta Pharmacol Sin
Asıl Yazarlar: Yuan, Tian-yi, Chen, Yu-cai, Zhang, Hui-fang, Li, Li, Jiao, Xiao-zhen, Xie, Ping, Fang, Lian-hua, Du, Guan-hua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857545/
https://ncbi.nlm.nih.gov/pubmed/27041459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.161
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