A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis

Background. Cryptococcal meningitis remains a significant cause of death among human immunodeficiency virus type 1 (HIV)–infected persons in Africa. We aimed to better understand the pathogenesis and identify immune correlates of mortality, particularly the role of monocyte activation. Methods. A pr...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Scriven, James E., Graham, Lisa M., Schutz, Charlotte, Scriba, Thomas J., Wilkinson, Katalin A., Wilkinson, Robert J., Boulware, David R., Urban, Britta C., Lalloo, David G., Meintjes, Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857465/
https://ncbi.nlm.nih.gov/pubmed/26768248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw007
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