Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis

BACKGROUND: Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA). NGF blockade has reduced arthritis pain in clinical...

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Pubblicato in:Arthritis Res Ther
Autori principali: Ashraf, Sadaf, Bouhana, Karyn S., Pheneger, Jed, Andrews, Steven W., Walsh, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857260/
https://ncbi.nlm.nih.gov/pubmed/27145816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0996-z
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