Evaluation of the Safety and Benefit of Phase I Oncology Trials for Patients With Primary CNS Tumors

PURPOSE: Patients with high-grade gliomas (HGG) are frequently excluded from first-in-human solid tumor trials because of perceived poor prognosis, excessive toxicities, concomitant drug interactions, and poor efficacy. We conducted an analysis of outcomes from select, single-agent phase I studies i...

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Bibliografische gegevens
Gepubliceerd in:J Clin Oncol
Hoofdauteurs: Gounder, Mrinal M., Nayak, Lakshmi, Sahebjam, Solmaz, Muzikansky, Alona, Sanchez, Armando J., Desideri, Serena, Ye, Xiaobu, Ivy, S. Percy, Nabors, L. Burt, Prados, Michael, Grossman, Stuart, DeAngelis, Lisa M., Wen, Patrick Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Clinical Oncology 2015
Onderwerpen:
Original Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857195/
https://ncbi.nlm.nih.gov/pubmed/26282642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.61.1525
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