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Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes

This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Dørum, Siri, Steinsbø, Øyvind, Bergseng, Elin, Arntzen, Magnus Ø., de Souza, Gustavo A., Sollid, Ludvig M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857092/
https://ncbi.nlm.nih.gov/pubmed/27146306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25565
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