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Trans-ethnic study design approaches for fine-mapping

Studies that traverse ancestrally diverse populations may increase power to detect novel loci and improve fine-mapping resolution of causal variants by leveraging linkage disequilibrium differences between ethnic groups. The inclusion of African ancestry samples may yield further improvements becaus...

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Bibliographic Details
Published in:Eur J Hum Genet
Main Authors: Asimit, Jennifer L, Hatzikotoulas, Konstantinos, McCarthy, Mark, Morris, Andrew P, Zeggini, Eleftheria
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856879/
https://ncbi.nlm.nih.gov/pubmed/26839038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.1
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