Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells

Immunoglobulin E (IgE) plays a key role in allergic asthma and is a clinically validated target for monoclonal antibodies. Therapeutic anti-IgE antibodies block the interaction between IgE and the Fc epsilon (Fcε) receptor, which eliminates or minimizes the allergic phenotype but does not typically...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Immunol
Autori principali: Nyborg, Andrew C, Zacco, Anna, Ettinger, Rachel, Jack Borrok, M, Zhu, Jie, Martin, Tom, Woods, Rob, Kiefer, Christine, Bowen, Michael A, Suzanne Cohen, E., Herbst, Ronald, Wu, Herren, Coats, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856805/
https://ncbi.nlm.nih.gov/pubmed/25942513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.19
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