Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality

PURPOSE: Poly(ADP-ribose) polymerase (PARP) inhibitors potentiate radiation therapy in preclinical models of human non-small cell lung cancer (NSCLC) and other types of cancer. However, the mechanisms underlying radiosensitization in vivo are incompletely understood. Herein, we investigated the impa...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Radiat Oncol Biol Phys
Auteurs principaux: Jiang, Yanyan, Verbiest, Tom, Devery, Aoife M., Bokobza, Sivan M., Weber, Anika M., Leszczynska, Katarzyna B., Hammond, Ester M., Ryan, Anderson J.
Format: Artigo
Langue:Inglês
Publié: Elsevier Science Inc 2016
Sujets:
Biology Contribution
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856738/
https://ncbi.nlm.nih.gov/pubmed/27020103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2016.01.035
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