Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

Acute and chronic hypoxia exists within the 3D microenvironment of solid tumors and drives therapy resistance, genetic instability and metastasis. Replicating cells exposed to either severe acute hypoxia (16 h with 0.02% O(2)) followed by reoxygenation or moderate chronic hypoxia (72 h with 0.2% O(2...

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Main Authors: Chan, Norman, Pires, Isabel M., Bencokova, Zuzana, Coackley, Carla, Luoto, Kaisa R., Bhogal, Nirmal, Lakshman, Minalini, Gottipati, Ponnari, Oliver, F. Javier, Helleday, Thomas, Hammond, Ester M., Bristow, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978949/
https://ncbi.nlm.nih.gov/pubmed/20924112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2352
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