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Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes

A central challenge in the analysis of genetic variation is to provide realistic genome simulation across millions of samples. Present day coalescent simulations do not scale well, or use approximations that fail to capture important long-range linkage properties. Analysing the results of simulation...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Kelleher, Jerome, Etheridge, Alison M, McVean, Gilean
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856371/
https://ncbi.nlm.nih.gov/pubmed/27145223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004842
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