Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we demonstrate interconverts UDP-GlcNAc and UDP-ManNAc to modulate substrate levels of TarO and TarA wall teichoic acid (WTA) biosynthesis enzymes. Gene...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Mann, Paul A., Müller, Anna, Wolff, Kerstin A., Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E., Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R., Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J., Pinho, Mariana G., Schneider, Tanja, Roemer, Terry
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856313/
https://ncbi.nlm.nih.gov/pubmed/27144276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005585
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