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Low-dimensionality in gene expression data enables the accurate extraction of transcriptional programs from shallow sequencing
A tradeoff between precision and throughput constrains all biological measurements, including sequencing-based technologies. Here, we develop a mathematical framework that defines this tradeoff between mRNA-sequencing depth and error in the extraction of biological information. We find that transcri...
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| Udgivet i: | Cell Syst |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4856162/ https://ncbi.nlm.nih.gov/pubmed/27135536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.04.001 |
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