Common type 2 diabetes-risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans

AIMS: The common MTNR1B genetic variant rs10830963 is associated with an increased risk of type 2 diabetes (T2D). To date, no experimental study has tested the effect of the MTNR1B variant on glucose metabolism in humans during exposure of the melatonin receptors to their ligand. The aim of this stu...

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Udgivet i:Metabolism
Main Authors: Garaulet, Marta, Gómez-Abellán, Purificación, Rubio-Sastre, Patricia, Madrid, Juan A, Saxena, Richa, Scheer, Frank AJL
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856010/
https://ncbi.nlm.nih.gov/pubmed/26440713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2015.08.003
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