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ProBNP(1–108) Is Resistant to Degradation and Activates Guanylyl Cyclase-A with Reduced Potency
BACKGROUND: B-type natriuretic peptide (BNP) compensates for the failing heart and is synthesized as a 108-residue prohormone that is cleaved to a 32-residue C-terminal maximally active peptide. During heart failure, serum concentrations of proBNP(1–108) exceed concentrations of BNP(1–32). The aim o...
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| Publicado no: | Clin Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4855511/ https://ncbi.nlm.nih.gov/pubmed/21768217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2011.169151 |
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