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Safety, stability and pharmacokinetic properties of (super)Factor Va, a novel engineered coagulation factor V for treatment of severe bleeding
PURPOSE: Activated (super)Factor V ((super)FVa) is a novel engineered FV with excellent prohemostatic efficacy. (Super)FVa has three APC cleavage site mutations and an interdomain disulfide bond. Stability, pharmacokinetics, and immunogenic and thrombogenic potential are reported here. METHODS: Stab...
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| Udgivet i: | Pharm Res |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854778/ https://ncbi.nlm.nih.gov/pubmed/26960296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-1895-3 |
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