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Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant
BACKGROUND: Factor (F)VIIa-based bypassing not always provides sufficient hemostasis in hemophilia. OBJECTIVES: To investigate the potential of engineered activated factor V (FVa) variants as bypassing agents in hemophilia A. METHODS: Activity of FVa variants was studied in vitro using prothrombinas...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4161283/ https://ncbi.nlm.nih.gov/pubmed/24818532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12489 |
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